Despite decades of research, we lack objective diagnostic or prognostic biomarkers of
mental health problems. A key reason for this limited progress is a reliance on the traditional …

Background More than 320 million people around the world suffer from depression. Physical
activity and sports are effective treatment strategies. Endurance training has already been …

This Comment highlights the intertwined nature of mental and brain health and disease.
Common genetic, environmental and lifestyle factors contribute to psychiatric and …

Depression and anxiety are prevalent in people with a chronic physical illness. Increasing
evidence suggests that co-occurring physical and mental illness is associated with shared …

Gene-environment interactions shape behavior and susceptibility to depression. However,
little is known about the signaling pathways integrating genetic and environmental inputs to …

The lifespan growth of the functional connectome remains unknown. Here, we assemble
task-free functional and structural magnetic resonance imaging data from 33,250 individuals …

Abstract Background and Hypotheses Several biological markers are believed to reflect
accelerated aging in schizophrenia spectrum disorders; however, retinal neural changes …

Objectives Postural Tachycardia Syndrome (PoTS) is a poorly understood syndrome of
multiple disabling symptoms. This study explored the process of seeking a diagnosis of …

Cardiometabolic and psychiatric disorders often co-exist and share common early life risk
factors, such as low birth weight. However, the biological pathways linking early adversity to …

The geroscience hypothesis asserts that physiological aging is caused by a small number of
biological pathways. Despite the explosion of geroscience research over the past couple of …