Virus‐like particles: Next‐generation nanoparticles for targeted therapeutic delivery

MJ Rohovie, M Nagasawa… - … & translational medicine, 2017 - Wiley Online Library
Most drug therapies distribute the agents throughout the entire body, even though the drugs
are typically only needed at specific tissues. This often limits dosage and causes discomfort …

Protein nanoparticles: promising platforms for drug delivery applications

A Jain, SK Singh, SK Arya, SC Kundu… - … Biomaterials Science & …, 2018 - ACS Publications
The development of drug delivery systems using nanoparticles as carriers for small and
large therapeutic molecules remains a rapidly growing area of research. The advantages of …

Challenges and opportunities for small molecule aptamer development

M McKeague, MC DeRosa - Journal of nucleic acids, 2012 - Wiley Online Library
Aptamers are single‐stranded oligonucleotides that bind to targets with high affinity and
selectivity. Their use as molecular recognition elements has emerged as a viable approach …

Aptamers from random sequence space: Accomplishments, gaps and future considerations

S Qian, D Chang, S He, Y Li - Analytica Chimica Acta, 2022 - Elsevier
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …

Nanoreactors by programmed enzyme encapsulation inside the capsid of the bacteriophage P22

DP Patterson, PE Prevelige, T Douglas - ACS nano, 2012 - ACS Publications
The virus like particle (VLP) derived from bacteriophage P22 presents a unique platform for
constructing catalytically functional nanomaterials by encapsulation of enzymes into its …

Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures

P Pushko, P Pumpens, E Grens - Intervirology, 2013 - karger.com
Virus-like particle (VLP) technology is a promising approach for the construction of novel
vaccines, diagnostic tools, and gene therapy vectors. Initially, VLPs were primarily derived …

Virus-like particle nanoreactors: programmed encapsulation of the thermostable CelB glycosidase inside the P22 capsid

DP Patterson, B Schwarz, K El-Boubbou… - Soft Matter, 2012 - pubs.rsc.org
Self-assembling biological systems hold great potential for the synthetic construction of new
active soft nanomaterials. Here we demonstrate the hierarchical bottom-up assembly of …

Heterologous Prime-Boost with Immunologically Orthogonal Protein Nanoparticles for Peptide Immunofocusing

S Bhattacharya, MC Jenkins, P Keshavarz-Joud… - ACS …, 2024 - ACS Publications
Protein nanoparticles are effective platforms for antigen presentation and targeting effector
immune cells in vaccine development. Encapsulins are a class of protein-based microbial …

Virus-like particle-based nanocarriers as an emerging platform for drug delivery

B Yuan, Y Liu, M Lv, Y Sui, S Hou, T Yang… - Journal of Drug …, 2023 - Taylor & Francis
New nanocarrier technologies are emerging, and they have great potential for improving
drug delivery, targeting efficiency and bioavailability. Virus-like particles (VLPs) are natural …

Boosting immunity to small tumor-associated carbohydrates with bacteriophage Qβ capsids

Z Yin, M Comellas-Aragones, S Chowdhury… - ACS chemical …, 2013 - ACS Publications
The development of an effective immunotherapy is an attractive strategy toward cancer
treatment. Tumor associated carbohydrate antigens (TACAs) are overexpressed on a variety …