Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …
biological questions and as building blocks for engineered tissues. Spheroids possess …
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer
E Suarez-Martinez, I Suazo-Sanchez, M Celis-Romero… - Cell & Bioscience, 2022 - Springer
In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …
extracellular molecules and niche soluble and mechanical signaling. These …
Mimicking native liver lobule microarchitecture in vitro with parenchymal and non-parenchymal cells using 3D bioprinting for drug toxicity and drug screening …
Bioengineering an in vitro liver model recapitulating the native liver microarchitecture
consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular …
consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular …
[HTML][HTML] Synthetic developmental biology: Engineering approaches to guide multicellular organization
Multicellular organisms of various complexities self-organize in nature. Organoids are in
vitro 3D structures that display important aspects of the anatomy and physiology of their in …
vitro 3D structures that display important aspects of the anatomy and physiology of their in …
Challenges for the applications of human pluripotent stem cell-derived liver organoids
The current organoid culture systems allow pluripotent and adult stem cells to self-organize
to form three-dimensional (3D) structures that provide a faithful recapitulation of the …
to form three-dimensional (3D) structures that provide a faithful recapitulation of the …
An in vivo tumour organoid model based on the chick embryonic chorioallantoic membrane mimics key characteristics of the patient tissue: a proof-of-concept study
K Benčurová, L Tran, J Friske, K Bevc, TH Helbich… - EJNMMI research, 2024 - Springer
Background Patient-derived tumour organoids (PDOs) are highly advanced in vitro models
for disease modelling, yet they lack vascularisation. To overcome this shortcoming …
for disease modelling, yet they lack vascularisation. To overcome this shortcoming …
Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues
The regulation of cellular behavior within a three-dimensional (3D) environment to execute a
specific function remains a challenge in the field of tissue engineering. In native tissues …
specific function remains a challenge in the field of tissue engineering. In native tissues …
Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model
Background Despite considerable advancements in identifying factors contributing to the
development of hepatocellular carcinoma (HCC), the pathogenesis of HCC remains unclear …
development of hepatocellular carcinoma (HCC), the pathogenesis of HCC remains unclear …
[HTML][HTML] Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) has become the world's most common chronic
liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development …
liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development …
In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system
Liver fibrosis is the late consequence of chronic liver inflammation which could eventually
lead to cirrhosis, and liver failure. Among various etiological factors, activated hepatic …
lead to cirrhosis, and liver failure. Among various etiological factors, activated hepatic …