Spinal cord injury (SCI) is a serious problem in the central nervous system resulting in high
disability and mortality with complex pathophysiological mechanisms. Oxidative stress is …

The endothelium is a complex organ system that controls the homeostasis of the vasculature
by integrating signals between the vascular wall and the vessel lumen. Under physiological …

Background—Recent clinical studies have suggested a major protective role for the
antioxidant enzyme glutathione peroxidase-1 (GPx1) in diabetes-associated …

Oxidative stress has been suggested to potentiate atherogenesis. However, studies that
have investigated the effect of antioxidants on atherosclerosis showed inconsistent results …

Accumulation of oxidized lipids in the arterial wall contributes to atherosclerosis. Glutathione
peroxidase-4 (GPx4) is a hydroperoxide scavenger that removes oxidative modifications …

The use of superoxide dismutases (SODs) in inflammatory diseases is hampered by their
short circulatory half-life. To determine whether a bacterial supply of SOD into the colon …

Aims: The objective of this study was to explore the effects of epigallocatechin-3-gallate
(EGCG) on type 2 diabetes mellitus (T2DM). Main methods: Male Sprague–Dawley rats …

Reactive oxygen species have been implicated as a cause of cancer and aging in
mammals. Mice deficient for the antioxidant enzyme CuZn-superoxide dismutase (Sod1) …

The carcinogenic polycylic aromatic hydrocarbon, benzo (a) pyrene (BaP), has been shown
to generate reactive oxygen species (ROS) and accelerate the development of …

BACKGROUND: Selective estrogen receptor modulators (SERMs), similar to estrogens,
possess vasoprotective effects by reducing release of reactive oxygen species. Little is …