Sarcopenia is characterized by loss of muscle and reduction in muscle strength that
contributes to higher mortality rate and increased incidence of fall and hospitalization in the …

Sumoylation is an essential post-translational modification that has evolved to regulate
intricate networks within emerging complexities of eukaryotic cells. Thousands of target …

Neurogenesis in the adult mammalian brain relies on the lifelong persistence of quiescent
neural stem cell (NSC) reservoirs. Little is known about the mechanisms that lead to the …

Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …

The human brain is composed of billions of cells, including neurons and glia, with an
undetermined number of subtypes. During the embryonic and early postnatal stages, the …

The transitions from develo** to adult quiescent and activated neural stem cells (NSCs)
are not well understood. Here, we use single-cell transcriptional profiling and lineage tracing …

The adult neurogenic niche in the hippocampus is maintained through activation of
reversibly quiescent neural stem cells (NSCs) with radial glia-like morphology (RGLs). Here …

The presence and identity of neural progenitors in the enteric nervous system (ENS) of
vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS …

The endocannabinoid system (ECS) governs and coordinates several physiological
processes through an integrated signaling network, which is responsible for inducing …

The damage and repair of DNA is a continuous process required to maintain genomic
integrity. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage and …