HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
T Dragic, V Litwin, GP Allaway, SR Martin, Y Huang… - Nature, 1996 - nature.com
The β-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ cells by primary,
non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env …
non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env …
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
RI Connor, BK Chen, S Choe, NR Landau - Virology, 1995 - Elsevier
HIV-1 vpr encodes a 96-amino acid, nuclear protein whose function is not well understood.
Unlike the other lentivirus regulatory proteins, Vpr is present in virions at relatively high copy …
Unlike the other lentivirus regulatory proteins, Vpr is present in virions at relatively high copy …
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
GA Donzella, D Schols, SW Lin, JA Esté… - Nature medicine, 1998 - nature.com
The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via
the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 …
the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 …
Reporter gene vectors and assays
E Schenborn, D Groskreutz - Molecular biotechnology, 1999 - Springer
Gene reporter systems play a key role in gene expression and regulation studies. This
review describes the ideal reporter systems, including reporter expression vector design. It …
review describes the ideal reporter systems, including reporter expression vector design. It …
Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target
DC Chan, CT Chutkowski… - Proceedings of the …, 1998 - National Acad Sciences
Synthetic C peptides, corresponding to the C helix of the HIV type 1 (HIV-1) gp41 envelope
protein, are potent inhibitors of HIV-1 membrane fusion. One such peptide is in clinical trials …
protein, are potent inhibitors of HIV-1 membrane fusion. One such peptide is in clinical trials …
Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket
DM Eckert, VN Malashkevich, LH Hong, PA Carr… - Cell, 1999 - cell.com
The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular
membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 …
membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 …
Marker proteins for gene expression
KV Wood - Current opinion in biotechnology, 1995 - Elsevier
Reporter genes are widely used as a rapid and convenient means of measuring molecular
genetic events. Their role in experimental strategies has expanded from analysis of the DNA …
genetic events. Their role in experimental strategies has expanded from analysis of the DNA …
Protein design of an HIV-1 entry inhibitor
Human immunodeficiency virus type–1 (HIV-1) membrane fusion is promoted by the
formation of a trimer-of-hairpins structure that brings the amino-and carboxyl-terminal …
formation of a trimer-of-hairpins structure that brings the amino-and carboxyl-terminal …
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
A Bosque, V Planelles - Blood, The Journal of the American …, 2009 - ashpublications.org
The use of antiretroviral therapy in HIV type 1 (HIV-1)–infected patients does not lead to
virus eradication. This is due, to a significant degree, to the fact that HIV-1 can establish a …
virus eradication. This is due, to a significant degree, to the fact that HIV-1 can establish a …
Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
JD Reeves, SA Gallo, N Ahmad… - Proceedings of the …, 2002 - National Acad Sciences
HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds
the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and …
the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and …