Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

Triple-negative breast cancer (TNBC) is a subset of breast cancer with aggressive
characteristics and few therapeutic options. The lack of an appropriate therapeutic target is a …

SHP2 phosphatase promotes full activation of the RTK-dependent Ras/MAPK pathway. Its
mutations can drive cancer and RASopathies, a group of neurodevelopmental disorders …

The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …

SHP2 plays a critical role in modulating tumor growth and PD-1-related signaling pathway,
thereby serving as an attractive antitumor target. To date, no antitumor drugs targeting SHP2 …

Natural products have been playing indispensable roles in the development of lifesaving
drug molecules. They are also valuable sources for covalent protein modifiers. However …

U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a multifunctional protein that plays a
crucial role in the regulation of RNA splicing during eukaryotic gene expression. U2AF1 …

Drug resistance continues to be a major problem associated with cancer treatment. One of
the primary causes of anticancer drug resistance is the frequently mutated RAS gene. In …

Triple negative breast cancer (TNBC) presents a formidable challenge due to the lack of
effective treatment modalities. Immunotherapy stands as a promising therapeutic approach; …

Liver cancer is the fourth most common cause of cancer‐related death worldwide, with
hepatocellular carcinoma (HCC) being the main primary malignancy affecting the liver …