OmicScope unravels systems-level insights from quantitative proteomics data

G Reis-de-Oliveira, VC Carregari, GRR Sousa… - Nature …, 2024 - nature.com
Shotgun proteomics analysis presents multifaceted challenges, demanding diverse tool
integration for insights. Addressing this complexity, OmicScope emerges as an innovative …

Proteomics reveals differentially regulated pathways when comparing grade 2 and 4 astrocytomas

DCA Verissimo, AC Camillo-Andrade, MDM Santos… - Plos one, 2023 - journals.plos.org
Astrocytic tumors are known for their high progression capacity and high mortality rates; in
this regard, proteins correlated to prognosis can aid medical conduct. Although several …

Key Proteomics Tools for Fundamental and Applied Microalgal Research

M Plouviez, E Dubreucq - Proteomes, 2024 - mdpi.com
Microscopic, photosynthetic prokaryotes and eukaryotes, collectively referred to as
microalgae, are widely studied to improve our understanding of key metabolic pathways (eg …

Urinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings

LM Brasileiro-Martins, SA Cavalcante… - PLOS Neglected …, 2024 - journals.plos.org
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming,
a neglected health problem in the Brazilian Amazon. Understanding the underlying …

Mebendazole Inhibits Histoplasma capsulatum In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels

MA Almeida, AR Bernardes-Engemann, RA Coelho… - Journal of Fungi, 2023 - mdpi.com
Histoplasmosis is a frequent mycosis in people living with HIV/AIDS and other
immunocompromised hosts. Histoplasmosis has high rates of mortality in these patients if …

Insights from a Multi-Omics Integration (MOI) Study in Oil Palm (Elaeis guineensis Jacq.) Response to Abiotic Stresses: Part One—Salinity

CB Bittencourt, TL Carvalho da Silva… - Plants, 2022 - mdpi.com
Oil palm (Elaeis guineensis Jacq.) is the number one source of consumed vegetable oil
nowadays. It is cultivated in areas of tropical rainforest, where it meets its natural condition of …

PatternLab V handles multiplex spectra in shotgun proteomic searches and increases identification

MA Clasen, MDM Santos, LU Kurt… - Journal of the …, 2023 - ACS Publications
Complex protein mixtures typically generate many tandem mass spectra produced by
different peptides coisolated in the gas phase. Widely adopted proteomic data analysis …

Target Discovery Driven by Chemical Biology and Computational Biology

B Lyu, W Gou, F Xu, L Chen, Z Wang… - The Chemical …, 2025 - Wiley Online Library
Target identification is crucial for drug screening and development because it can reveal the
mechanism of drug action and ensure the reliability and accuracy of the results. Chemical …

Differential precipitation of proteins: A simple protein fractionation strategy to gain biological insights with proteomics

AFM Pinto, JK Diedrich, JJ Moresco… - Journal of the American …, 2023 - ACS Publications
Differential precipitation of proteins (DiffPOP) is a simple technique for fractionating complex
protein mixtures. Using stepwise addition of acidified methanol, ten distinct subsets of …

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation

M Martinez, J Petit, A Leyva, A Sogues, D Megrian… - Nature …, 2023 - nature.com
The order Corynebacteriales includes major industrial and pathogenic Actinobacteria such
as Corynebacterium glutamicum or Mycobacterium tuberculosis. These bacteria have multi …