Neurodegeneration describes the loss of neuronal structure and function. Numerous
neurodegenerative diseases are associated with neurodegeneration. Many are rare and …

This review on the role of neurofilaments as surrogate markers for axonal degeneration in
neurological diseases provides a brief background to protein synthesis, assembly, function …

Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by
death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial …

Background The progressive nature of Wallerian degeneration has long been controversial.
Conflicting reports that distal stumps of injured axons degenerate anterogradely …

During the past decade, hypotheses concerning the pathogenesis of most
neurodegenerative diseases have been dominated by the notion that the aggregation of …

Recent evidence showing that intermediate filaments (IFs) are dynamic, motile elements of
the cytoskeletal repertoire of vertebrate cells has overturned the long-standing view that they …

Traumatic brain injury (TBI) is a serious public health concern and a major cause of death
and disability worldwide. Each year, an estimated 1.7 million Americans sustain TBI of …

Abstract Charcot–Marie–Tooth disease (CMT) is the most common inherited disorder of the
peripheral nervous system, and mutations in neurofilaments have been linked to some forms …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the
degeneration of upper and lower motor neurons. Defects in axonal transport have been …

Neurofilaments are one of the major components of the neuronal cytoskeleton and are
responsible for maintaining the calibre of axons. They are modified by post‐translational …