Key steps for effective breast cancer prevention
Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
Targeting macrophages: therapeutic approaches in cancer
L Cassetta, JW Pollard - Nature reviews Drug discovery, 2018 - nature.com
Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
RGG Russell, NB Watts, FH Ebetino… - Osteoporosis …, 2008 - Springer
Bisphosphonates (BPs) are well established as the leading drugs for the treatment of
osteoporosis. There is new knowledge about how they work. The differences that exist …
osteoporosis. There is new knowledge about how they work. The differences that exist …
Endocrine therapy plus zoledronic acid in premenopausal breast cancer
M Gnant, B Mlineritsch, W Schip**er… - … England Journal of …, 2009 - Mass Medical Soc
Background Ovarian suppression plus tamoxifen is a standard adjuvant treatment in
premenopausal women with endocrine-responsive breast cancer. Aromatase inhibitors are …
premenopausal women with endocrine-responsive breast cancer. Aromatase inhibitors are …
Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects
Purpose: To investigate the role of macrophages in tumor progression under sorafenib
treatment and to explore whether combination of drugs that deplete macrophages improved …
treatment and to explore whether combination of drugs that deplete macrophages improved …
Bone and brain metastasis in lung cancer: recent advances in therapeutic strategies
C D'Antonio, A Passaro, B Gori… - … in medical oncology, 2014 - journals.sagepub.com
Bone and brain metastases are a very common secondary localization of disease in patients
with lung cancer. The prognosis of these patients is still poor with a median survival of less …
with lung cancer. The prognosis of these patients is still poor with a median survival of less …
[HTML][HTML] Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel
M Aapro, PA Abrahamsson, JJ Body, RE Coleman… - Annals of oncology, 2008 - Elsevier
Abstract Bisphosphonates (BP) prevent, reduce, and delay cancer-related skeletal
complications in patients, and have substantially decreased the prevalence of such events …
complications in patients, and have substantially decreased the prevalence of such events …
Zoledronic acid repolarizes tumour‐associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway
It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against
tumours not located in bone. Mice transgenic for the activated ErbB‐2 oncogene were …
tumours not located in bone. Mice transgenic for the activated ErbB‐2 oncogene were …
Pharmacology of bisphosphonates
S Cremers, S Papapoulos - Bone, 2011 - Elsevier
Four decades of preclinical and clinical research of the pharmacology of bisphosphonates
have generated data and concepts that have considerably improved their clinical use …
have generated data and concepts that have considerably improved their clinical use …
Breast cancer in young women
CA Gabriel, SM Domchek - Breast cancer research, 2010 - Springer
Although uncommon, breast cancer in young women is worthy of special attention due to the
unique and complex issues that are raised. This article reviews specific challenges …
unique and complex issues that are raised. This article reviews specific challenges …