von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends
PJ Lenting, OD Christophe… - Blood, The Journal of the …, 2015 - ashpublications.org
To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …
pathogenesis of related disorders, it is not only of interest to determine its function but also …
The relationship between ABO blood group, von Willebrand factor, and primary hemostasis
Numerous studies have reported significant associations between ABO blood group and risk
of cardiovascular disease. These studies have consistently demonstrated that thrombotic …
of cardiovascular disease. These studies have consistently demonstrated that thrombotic …
Evaluating the atrial myopathy underlying atrial fibrillation: identifying the arrhythmogenic and thrombogenic substrate
JJ Goldberger, R Arora, D Green, P Greenland… - Circulation, 2015 - Am Heart Assoc
Atrial disease or myopathy forms the substrate for atrial fibrillation (AF) and underlies the
potential for atrial thrombus formation and subsequent stroke. Current diagnostic …
potential for atrial thrombus formation and subsequent stroke. Current diagnostic …
ADAMTS13 regulation of VWF multimer distribution in severe COVID‐19
Background Consistent with fulminant endothelial cell activation, elevated plasma von
Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The …
Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The …
ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura
XL Zheng - Annual review of medicine, 2015 - annualreviews.org
Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a
century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver …
century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver …
[HTML][HTML] Von Willebrand factor and cancer; metastasis and coagulopathies
Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates
platelet adhesion along the endothelium. In addition to its role maintaining normal …
platelet adhesion along the endothelium. In addition to its role maintaining normal …
Tumor cell-induced platelet aggregation as an emerging therapeutic target for cancer therapy
W Strasenburg, J Jóźwicki, J Durślewicz… - Frontiers in …, 2022 - frontiersin.org
Tumor cells have the ability to induce platelet activation and aggregation. This has been
documented to be involved in tumor progression in several types of cancers, such as lung …
documented to be involved in tumor progression in several types of cancers, such as lung …
ABO blood group and thrombotic vascular disease
M Franchini, PM Mannucci - Thrombosis and haemostasis, 2014 - thieme-connect.com
ABO blood group antigens are complex carbohydrate molecules expressed on red blood
cells and a variety of tissues. The ABO blood type is implicated in the development of a …
cells and a variety of tissues. The ABO blood type is implicated in the development of a …
[HTML][HTML] Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms
S Albánez, K Ogiwara, A Michels, W Hopman… - Journal of Thrombosis …, 2016 - Elsevier
Essentials• von Willebrand factor (VWF) and factor VIII (FVIII) levels are modulated by age
and ABO status.• The effect of aging and ABO blood type on VWF and FVIII was assessed in …
and ABO status.• The effect of aging and ABO blood type on VWF and FVIII was assessed in …
von Willebrand factor clearance–biological mechanisms and clinical significance
The mechanisms involved in regulating von Willebrand factor (VWF) clearance remain
poorly understood. However recent studies have shown that macrophages play a critical …
poorly understood. However recent studies have shown that macrophages play a critical …