[HTML][HTML] Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells

U Testa, G Castelli, E Pelosi - Cancers, 2018‏ - mdpi.com
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond

T Schaefer, C Lengerke - Oncogene, 2020‏ - nature.com
Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …

[HTML][HTML] Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

KA Hoadley, C Yau, DM Wolf, AD Cherniack… - Cell, 2014‏ - cell.com
Recent genomic analyses of pathologically defined tumor types identify" within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across …

SOX2 and cancer: current research and its implications in the clinic

K Weina, J Utikal - Clinical and translational medicine, 2014‏ - Springer
SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

[HTML][HTML] SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior

JL Sauter, RP Graham, BT Larsen, SM Jenkins… - Modern Pathology, 2017‏ - Elsevier
A distinct subset of thoracic sarcomas with undifferentiated rhabdoid morphology and
SMARCA4 inactivation has recently been described, and potential targeted therapy for …

Extracellular serine controls epidermal stem cell fate and tumour initiation

SC Baksh, PK Todorova, S Gur-Cohen, B Hurwitz… - Nature cell …, 2020‏ - nature.com
Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the
balance between self-renewal and differentiation, but whether endogenous metabolic …

Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication

S Kaufhold, H Garbán, B Bonavida - Journal of Experimental & Clinical …, 2016‏ - Springer
Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous
tissues compared to normal tissues and has regulatory roles in cell proliferation, cell …

SOX2 mediates metabolic reprogramming of prostate cancer cells

L de Wet, A Williams, M Gillard, S Kregel, S Lamperis… - Oncogene, 2022‏ - nature.com
New strategies are needed to predict and overcome metastatic progression and therapy
resistance in prostate cancer. One potential clinical target is the stem cell transcription factor …

Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression

MÁ Marqués-Torrejón, E Porlan, A Banito… - Cell stem cell, 2013‏ - cell.com
In the adult brain, continual neurogenesis of olfactory neurons is sustained by the existence
of neural stem cells (NSCs) in the subependymal niche. Elimination of the cyclin-dependent …

Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer

S Kregel, KJ Kiriluk, AM Rosen, Y Cai, EE Reyes… - PloS one, 2013‏ - journals.plos.org
Despite advances in detection and therapy, castration-resistant prostate cancer continues to
be a major clinical problem. The aberrant activity of stem cell pathways, and their regulation …