Design and synthesis of novel antimicrobial agents
Z Breijyeh, R Karaman - Antibiotics, 2023 - mdpi.com
The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …
Drug discovery in tuberculosis. New drug targets and antimycobacterial agents
A Campaniço, R Moreira, F Lopes - European journal of medicinal …, 2018 - Elsevier
Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …
Recent advancements in the development of anti-tuberculosis drugs
S Chetty, M Ramesh, A Singh-Pillay… - Bioorganic & medicinal …, 2017 - Elsevier
Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase
S Wellington, PP Nag, K Michalska… - Nature chemical …, 2017 - nature.com
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential
functions, but only a small fraction of such processes—primarily those involved in …
functions, but only a small fraction of such processes—primarily those involved in …
The present state of the tuberculosis drug development pipeline
MDJ Libardo, HIM Boshoff, CE Barry III - Current opinion in pharmacology, 2018 - Elsevier
Tuberculosis now ranks as the leading cause of death in the world due to a single infectious
agent. Current standard of care treatment can achieve very high cure rates for drug-sensitive …
agent. Current standard of care treatment can achieve very high cure rates for drug-sensitive …
Exploring the allosteric territory of protein function
WV Tee, ZW Tan, K Lee, E Guarnera… - The journal of physical …, 2021 - ACS Publications
While the pervasiveness of allostery in proteins is commonly accepted, we further show the
generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel …
generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel …
Cellulase production and efficient saccharification of biomass by a new mutant Trichoderma afroharzianum MEA-12
ZQ Peng, C Li, Y Lin, SS Wu, LH Gan, J Liu… - Biotechnology for …, 2021 - Springer
Background Cellulase plays a key role in converting cellulosic biomass into fermentable
sugar to produce chemicals and fuels, which is generally produced by filamentous fungi …
sugar to produce chemicals and fuels, which is generally produced by filamentous fungi …
Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis
N Ruecker, R Jansen, C Trujillo, S Puckett… - Cell chemical …, 2017 - cell.com
Enzymes of central carbon metabolism are essential mediators of Mycobacterium
tuberculosis (Mtb) physiology and pathogenicity, but are often perceived to lack sufficient …
tuberculosis (Mtb) physiology and pathogenicity, but are often perceived to lack sufficient …
Protein targets in Mycobacterium tuberculosis and their inhibitors for therapeutic implications: A narrative review
S Sreelatha, U Nagarajan, S Natarajan - International Journal of Biological …, 2023 - Elsevier
Advancement in the area of anti-tubercular drug development has been full-fledged, yet, a
very less number of drug molecules have reached phase II clinical trials, and therefore “End …
very less number of drug molecules have reached phase II clinical trials, and therefore “End …
Opportunities for overcoming tuberculosis: Emerging targets and their inhibitors
Tuberculosis (TB), an airborne infectious disease mainly caused by Mycobacterium
tuberculosis (Mtb), remains a leading cause of human morbidity and mortality worldwide …
tuberculosis (Mtb), remains a leading cause of human morbidity and mortality worldwide …