Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …

More than 100 different blood and urine biomarkers have been described in sickle cell
disease (SCD), with the number increasing rapidly as analytical techniques develop. Nearly …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Abstract The “hyperhemolytic paradigm”(HHP) posits that hemolysis in sickle disease
sequentially and causally establishes increased cell‐free plasma Hb, consumption of NO, a …

Background—Noninvasively assessed pulmonary pressure elevations and left ventricular
(LV) diastolic dysfunction are associated with increased mortality in adults with sickle cell …

Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO)
bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO …

Background Sickle Cell Disease (SCD) is an inherited blood disorder that leads to hemolytic
anemia, pain, organ damage and early mortality. It is characterized by polymerized …

Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red
blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the …

Hypoxemia is common in SCD and likely exacerbates SCD vasculopathy. Pulse oximeter
correlation with arterial oxygen tension in patients with SCD may at times be poor and …

Sickle cell disease (SCD) is caused by a single point mutation in the gene that codes for
beta globin synthesis, causing haemoglobin polymerisation, red blood cell stiffening and …