Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023‏ - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

[HTML][HTML] Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy

S Fu, G Li, W Zang, X Zhou, K Shi, Y Zhai - Acta Pharmaceutica Sinica B, 2022‏ - Elsevier
Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to
the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are …

Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers

S Mazumdar, D Chitkara, A Mittal - Acta Pharmaceutica Sinica B, 2021‏ - Elsevier
The beneficial or deleterious effects of nanomedicines emerge from their complex
interactions with intracellular pathways and their subcellular fate. Moreover, the dynamic …

The in vitro and in vivo toxicity of gold nanoparticles

YP Jia, BY Ma, XW Wei, ZY Qian - Chinese Chemical Letters, 2017‏ - Elsevier
Gold nanoparticles, owing to their unique physicochemical and optical properties, well-
established synthetic methods and easy modifications, have been widely used in biomedical …

Dissipative particle dynamics simulations in colloid and Interface science: A review

KP Santo, AV Neimark - Advances in colloid and interface science, 2021‏ - Elsevier
Dissipative particle dynamics (DPD) is one of the most efficient mesoscale coarse-grained
methodologies for modeling soft matter systems. Here, we comprehensively review the …

Cellular uptake of nanoparticles as determined by particle properties, experimental conditions, and cell type

K Kettler, K Veltman, D van De Meent… - Environmental …, 2014‏ - academic.oup.com
The increased application of nanoparticles (NPs) is increasing the risk of their release into
the environment. Although many toxicity studies have been conducted, the environmental …

The influence of nanoparticle properties on oral bioavailability of drugs

Y Wang, C Pi, X Feng, Y Hou, L Zhao… - International Journal of …, 2020‏ - Taylor & Francis
Oral administration has been the most common therapeutic regimen in various diseases
because of its high safety, convenience, lower costs, and high compliance of patients …

Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application

X Zhang, G Ma, W Wei - NPG Asia Materials, 2021‏ - nature.com
Nanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for
potential applications in biomedicine. During their delivery and functionalization within the …

Understanding cellular interactions with nanomaterials: Towards a rational design of medical nanodevices

F Villanueva-Flores, A Castro-Lugo, OT Ramírez… - …, 2020‏ - iopscience.iop.org
Biomedical applications increasingly require fully characterized new nanomaterials. There is
strong evidence showing that nanomaterials not only interact with cells passively but also …

Membrane wrap** efficiency of elastic nanoparticles during endocytosis: size and shape matter

Z Shen, H Ye, X Yi, Y Li - ACS nano, 2018‏ - ACS Publications
Using coarse-grained molecular dynamics simulations, we systematically investigate the
receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging …