Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX)
maintenance therapy are poorly understood, but the benefits of several years of …

In high-income countries (HICs), the annual incidence of childhood cancer is approximately
140 per 1 million children younger than age 15 years, although estimates vary between and …

PURPOSE The ALL10 protocol improved outcomes for children with ALL by stratifying and
adapting therapy into three minimal residual disease–defined risk groups: standard risk …

Altered expression of histone deacetylases (HDACs) is a common feature in several human
malignancies and may represent an interesting target for cancer treatment, including …

Acute lymphoblastic leukemia (ALL) can be classified into different subgroups based on
recurrent genetic alterations. Here, targeted RNA sequencing was used to identify the novel …

Abstract Treatment-related mortality is common among children with acute lymphoblastic
leukemia (ALL) treated in poor-resource settings. We applied a simplified flow cytometric …

The present study aimed to analyze the expression profile of the microRNAs previously
described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a …

BACKGROUND: Abandonment of therapy is a significant cause of paediatric cancer
treatment failure in low-to middle-income countries (LMIC), but its impact has been …

Objective To characterize ocular manifestations (OM) of pediatric patients treating for acute
lymphoblastic leukemia (ALL) and to evaluate whether they are associated with well …