Mass spectrometry-based techniques to elucidate the sugar code

M Grabarics, M Lettow, C Kirschbaum, K Greis… - Chemical …, 2021 - ACS Publications
Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Hyperbolic shear polaritons in low-symmetry crystals

NC Passler, X Ni, G Hu, JR Matson, G Carini, M Wolf… - Nature, 2022 - nature.com
The lattice symmetry of a crystal is one of the most important factors in determining its
physical properties. Particularly, low-symmetry crystals offer powerful opportunities to control …

Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy

C Manz, K Pagel - Current Opinion in Chemical Biology, 2018 - Elsevier
Highlights•Ion mobility-mass spectrometry (IM-MS) based methods can be used to elucidate
complex glycans.•IM-MS enables coarse separation of molecular classes and rapid …

An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies

J Seo, W Hoffmann, S Warnke, X Huang, S Gewinner… - Nature …, 2017 - nature.com
Amyloidogenic peptides and proteins play a crucial role in a variety of neurodegenerative
disorders such as Alzheimer's and Parkinson's disease. These proteins undergo a …

Glycan fingerprinting via cold‐ion infrared spectroscopy

E Mucha, AI González Flórez… - Angewandte Chemie …, 2017 - Wiley Online Library
The diversity of stereochemical isomers present in glycans and glycoconjugates poses a
formidable challenge for comprehensive structural analysis. Typically, sophisticated mass …

Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy

C Kirschbaum, K Greis, E Mucha, L Kain… - Nature …, 2021 - nature.com
Glycolipids are complex glycoconjugates composed of a glycan headgroup and a lipid
moiety. Their modular biosynthesis creates a vast amount of diverse and often isomeric …

Retention of native protein structures in the absence of solvent: a coupled ion mobility and spectroscopic study

J Seo, W Hoffmann, S Warnke… - Angewandte Chemie …, 2016 - Wiley Online Library
Can the structures of small to medium‐sized proteins be conserved after transfer from the
solution phase to the gas phase? A large number of studies have been devoted to this topic …

Unravelling the structure of glycosyl cations via cold-ion infrared spectroscopy

E Mucha, M Marianski, FF Xu, DA Thomas… - Nature …, 2018 - nature.com
Glycosyl cations are the key intermediates during the glycosylation reaction that covalently
links building blocks during the synthetic assembly of carbohydrates. The exact structure of …

The influence of the electron density in acyl protecting groups on the selectivity of galactose formation

K Greis, S Leichnitz, C Kirschbaum… - Journal of the …, 2022 - ACS Publications
The stereoselective formation of 1, 2-cis-glycosidic bonds is a major bottleneck in the
synthesis of carbohydrates. We here investigate how the electron density in acyl protecting …

Strong coupling of epsilon-near-zero phonon polaritons in polar dielectric heterostructures

NC Passler, CR Gubbin, TG Folland, I Razdolski… - Nano …, 2018 - ACS Publications
We report the first observation of epsilon-near-zero (ENZ) phonon polaritons in an ultrathin
AlN film fully hybridized with surface phonon polaritons (SPhP) supported by the adjacent …