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Mass spectrometry-based techniques to elucidate the sugar code
Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …
and glycans. Although glycans are essential to all living organisms, surprisingly little is …
Hyperbolic shear polaritons in low-symmetry crystals
The lattice symmetry of a crystal is one of the most important factors in determining its
physical properties. Particularly, low-symmetry crystals offer powerful opportunities to control …
physical properties. Particularly, low-symmetry crystals offer powerful opportunities to control …
Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy
Highlights•Ion mobility-mass spectrometry (IM-MS) based methods can be used to elucidate
complex glycans.•IM-MS enables coarse separation of molecular classes and rapid …
complex glycans.•IM-MS enables coarse separation of molecular classes and rapid …
An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies
Amyloidogenic peptides and proteins play a crucial role in a variety of neurodegenerative
disorders such as Alzheimer's and Parkinson's disease. These proteins undergo a …
disorders such as Alzheimer's and Parkinson's disease. These proteins undergo a …
Glycan fingerprinting via cold‐ion infrared spectroscopy
E Mucha, AI González Flórez… - Angewandte Chemie …, 2017 - Wiley Online Library
The diversity of stereochemical isomers present in glycans and glycoconjugates poses a
formidable challenge for comprehensive structural analysis. Typically, sophisticated mass …
formidable challenge for comprehensive structural analysis. Typically, sophisticated mass …
Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy
C Kirschbaum, K Greis, E Mucha, L Kain… - Nature …, 2021 - nature.com
Glycolipids are complex glycoconjugates composed of a glycan headgroup and a lipid
moiety. Their modular biosynthesis creates a vast amount of diverse and often isomeric …
moiety. Their modular biosynthesis creates a vast amount of diverse and often isomeric …
Retention of native protein structures in the absence of solvent: a coupled ion mobility and spectroscopic study
Can the structures of small to medium‐sized proteins be conserved after transfer from the
solution phase to the gas phase? A large number of studies have been devoted to this topic …
solution phase to the gas phase? A large number of studies have been devoted to this topic …
Unravelling the structure of glycosyl cations via cold-ion infrared spectroscopy
Glycosyl cations are the key intermediates during the glycosylation reaction that covalently
links building blocks during the synthetic assembly of carbohydrates. The exact structure of …
links building blocks during the synthetic assembly of carbohydrates. The exact structure of …
The influence of the electron density in acyl protecting groups on the selectivity of galactose formation
The stereoselective formation of 1, 2-cis-glycosidic bonds is a major bottleneck in the
synthesis of carbohydrates. We here investigate how the electron density in acyl protecting …
synthesis of carbohydrates. We here investigate how the electron density in acyl protecting …
Strong coupling of epsilon-near-zero phonon polaritons in polar dielectric heterostructures
We report the first observation of epsilon-near-zero (ENZ) phonon polaritons in an ultrathin
AlN film fully hybridized with surface phonon polaritons (SPhP) supported by the adjacent …
AlN film fully hybridized with surface phonon polaritons (SPhP) supported by the adjacent …