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Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Overweight and obesity are characterized by excessive fat mass accumulation produced
when energy intake exceeds energy expenditure. One plausible way to control energy …
when energy intake exceeds energy expenditure. One plausible way to control energy …
Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology …
Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …
Gut microbiota regulation of tryptophan metabolism in health and disease
The gut microbiota is a crucial actor in human physiology. Many of these effects are
mediated by metabolites that are either produced by the microbes or derived from the …
mediated by metabolites that are either produced by the microbes or derived from the …
The kynurenine pathway: a finger in every pie
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort …
Objective Tryptophan can be catabolised to various metabolites through host kynurenine
and microbial indole pathways. We aimed to examine relationships of host and microbial …
and microbial indole pathways. We aimed to examine relationships of host and microbial …
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health
BACKGROUND The essential amino acid tryptophan is a substrate for the generation of
several bioactive compounds with important physiological roles. Only a small fraction of …
several bioactive compounds with important physiological roles. Only a small fraction of …
Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling
T Huang, J Song, J Gao, J Cheng, H **e… - Nature …, 2022 - nature.com
Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …
Brain–gut–microbiome interactions in obesity and food addiction
Normal eating behaviour is coordinated by the tightly regulated balance between intestinal
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …
Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models
X Ge, M Zheng, M Hu, X Fang, D Geng, S Liu… - The Journal of clinical …, 2023 - jci.org
Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction,
including Alzheimer's disease. Low-grade inflammation is common in obesity, but the …
including Alzheimer's disease. Low-grade inflammation is common in obesity, but the …
Kynurenine pathway in diabetes mellitus—novel pharmacological target?
K Kozieł, EM Urbanska - Cells, 2023 - mdpi.com
The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion
in the brain and in the periphery. Kynurenines display a wide range of biological actions …
in the brain and in the periphery. Kynurenines display a wide range of biological actions …