Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

The proliferation of increasingly more sophisticated analytical separation systems, often
incorporating increasingly more powerful detection techniques, such as high‐resolution …

In recent years, mass spectrometry (MS)-based metabolomics has been extensively applied
to characterize biochemical mechanisms, and study physiological processes and …

Malignant melanoma (MM) is the most aggressive and life‐threatening form of skin cancer. It
is characterized by an extraordinary metastasis capacity and chemotherapy resistance …

Immune checkpoint inhibition has transformed the treatment landscape of advanced
melanoma and long-term survival of patients is now possible. However, at least half of the …

Aerobic glycolysis is a hallmark of cancer. Sine oculis homeobox 1 (SIX1), a key
transcription factor in terms of regulating aerobic glycolysis (the Warburg Effect), plays a …

Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show
additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan …

Simple Summary Studying the metabolome, the complete set of metabolites found in a
biological sample, helps to understand how metabolism differs between healthy and …

The incidence of melanoma, a very aggressive skin cancer, has increased over the past few
decades. Although there are well-established clinical, dermoscopic and histopathological …

Abstract Purpose Indoleamine 2, 3-dioxygenase-1 (IDO1) and more recently, tryptophan 2, 3-
dioxygenase (TDO), are tryptophan-catabolizing enzymes with immunoregulatory properties …