Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by
pathological T cell–B cell interactions,. Expansion of T follicular helper (TFH) and T …

Follicular helper T cells (T FH) are essential B cell-help providers in the formation of
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …

The interactions of CD4+ T cells and B cells are fundamental for the generation of protective
antibody responses, as well as for the development of harmful autoimmune diseases …

CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

Autoimmune diseases are associated with a dramatically increased risk of atherosclerotic
cardiovascular disease and its clinical manifestations. The increased risk is consistent with …