Ovarian cancer is the fifth cause of cancer-related deaths in women with high grade serous
carcinoma (HGSOC) representing the most common histological subtype. Approximately …

Cell response to genotoxic stress requires a complex network of sensors and effectors from
numerous signaling and repair pathways, among them the nuclear poly (ADP-ribose) …

It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its
metabolites contribute to DNA repair is largely unknown. In this study, we found that …

Abstract Poly (ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze
the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at …

Background PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA
damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to …

Breast cancer is one of the most common malignancies in women. Patient-derived tumor
xenograft (PDX) model is a cutting-edge approach for drug research on breast cancer …

Lymphocyte development requires ordered assembly and subsequent modifications of the
antigen receptor genes through V (D) J recombination and Immunoglobulin class switch …

Abstract Human ARTD2 (or PARP2) is an ADP-ribosyltransferase, which is catalytically
activated by binding to damaged DNA. ARTD2 subsequently ADP-ribosylates itself and …

Ovarian cancer is the most lethal gynecologic malignancy with a high recurrence rate. Poly
(ADP-ribose) polymerase inhibitors (PARPi) are one of the most active new therapies for …

Poly ADP ribose polymerase-1 (PARP-1), one of the most important members of the PARP
protein family, plays a crucial role in DNA damage repair, gene transcription, and apoptosis …