The assessment of safety and efficacy of therapeutics for children and adolescents requires
the use of multi-centered designs. However, the need to obtain ethical approval from …

There is near universal recognition that human participant protection is both morally and
practically essential for all forms of research involving humans. Yet most of the discourse …

Investigator-initiated clinical trials–also known as non-regulatory or academic clinical trials,
are conducted by investigators from academia or research organizations. They usually aim …

The Ontario Cancer Research Ethics Board (ocreb) has made its mark within Ontario as a
successful, centralized, oncology-specific research ethics board. As such, ocreb has proven …

umerous studies have identified the chal lenges researchers face when attempting to obtain
ethics approval for multisite studies. For instance, Greene and Geiger have identified delays …

Sir—In the January 2008 issue of Palliative Medicine, we were interested to read the letter to
the editor calling for international multisite research. As paediatric palliative care …

Purpose We describe issues and outcomes in the development of a specialized, central
institutional review board (IRB) for multicenter oncology protocols. Numerous authoritative …

INTRODUCTION: Individual institutions govern research ethics applications and each must
administer and regulate their own protocols. Variations in ethics review procedures and …

Large scale, multisite clinical research trials have been increasing in frequency. As it stands
currently, a research project performed at multiple institutions requires ethics review at each …

Aim: To describe the process involved in obtaining ethics approval for a study aiming to
recruit women from all maternity hospitals in Victoria, Australia. Design: Observational data …