Anti‐vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity

MJ Sankar, J Sankar, P Chandra - Cochrane Database of …, 2018 - cochranelibrary.com
Background Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis in
foetal life. Researchers have recently attempted to use anti‐VEGF agents for the treatment of …

Pathophysiology, screening and treatment of ROP: a multi-disciplinary perspective

T Chan-Ling, GA Gole, GE Quinn, SJ Adamson… - Progress in retinal and …, 2018 - Elsevier
The population of infants at risk for retinopathy of prematurity (ROP) varies by world region;
in countries with well developed neonatal intensive care services, the highest risk infants are …

Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled …

A Stahl, D Lepore, A Fielder, B Fleck, JD Reynolds… - The Lancet, 2019 - thelancet.com
Background Despite increasing worldwide use of anti-vascular endothelial growth factor
agents for treatment of retinopathy of prematurity (ROP), there are few data on their ocular …

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life

P Sapieha, JS Joyal, JC Rivera… - The Journal of clinical …, 2010 - jci.org
Retinopathy of prematurity (ROP) is a major complication of preterm birth. It encompasses a
spectrum of pathologies that affect vision, from mild disease that resolves spontaneously to …

Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies

JC Rivera, M Holm, D Austeng, TS Morken… - Journal of …, 2017 - Springer
Retinopathy of prematurity (ROP) is an important cause of childhood blindness globally, and
the incidence is rising. The disease is characterized by initial arrested retinal vascularization …

Serum levels of vascular endothelial growth factor and related factors after intravitreous bevacizumab injection for retinopathy of prematurity

WC Wu, R Lien, PJ Liao, NK Wang, YP Chen… - JAMA …, 2015 - jamanetwork.com
Importance Intravitreous injections of bevacizumab (IVB) have been found to be effective for
the treatment of retinopathy of prematurity (ROP). However, serum levels of vascular …

Role of the retinal vascular endothelial cell in ocular disease

AS Bharadwaj, B Appukuttan, PA Wilmarth… - Progress in retinal and …, 2013 - Elsevier
Retinal endothelial cells line the arborizing microvasculature that supplies and drains the
neural retina. The anatomical and physiological characteristics of these endothelial cells are …

Current update on retinopathy of prematurity: screening and treatment

J Chen, A Stahl, A Hellstrom… - Current opinion in …, 2011 - journals.lww.com
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Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

Y Fukushima, M Okada, H Kataoka, M Hirashima… - The Journal of clinical …, 2011 - jci.org
During development, the retinal vasculature grows toward hypoxic areas in an organized
fashion. By contrast, in ischemic retinopathies, new blood vessels grow out of the retinal …

Neurodevelopmental outcomes in infants with retinopathy of prematurity and bevacizumab treatment

R Lien, MH Yu, KH Hsu, PJ Liao, YP Chen, CC Lai… - PloS one, 2016 - journals.plos.org
Purpose The current study aims to investigate the neurodevelopment of premature infants
after intravitreal injections of bevacizumab (IVB) for the treatment of retinopathy of …