Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment
Y Zhao, X Zhang, X Chen… - … journal of molecular …, 2022 - spandidos-publications.com
Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …
Excitotoxicity: bridge to various triggers in neurodegenerative disorders
Glutamate is one of the most prominent neurotransmitter in the body, present in over 50% of
nervous tissue and plays an important role in neuronal excitation. This neuronal excitation is …
nervous tissue and plays an important role in neuronal excitation. This neuronal excitation is …
Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies
Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …
Revealing the contribution of astrocytes to glutamatergic neuronal transmission
Research on glutamatergic neurotransmission has focused mainly on the function of
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …
NMDA receptors: linking physiological output to biophysical operation
GJ Iacobucci, GK Popescu - Nature Reviews Neuroscience, 2017 - nature.com
NMDA receptors are preeminent neurotransmitter-gated channels in the CNS, which
respond to glutamate in a manner that integrates multiple external and internal cues. They …
respond to glutamate in a manner that integrates multiple external and internal cues. They …
Dysfunctional synapse in Alzheimer's disease–A focus on NMDA receptors
SI Mota, IL Ferreira, AC Rego - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations
capable of causing brain circuitry dysfunctions in AD may take several years to develop …
capable of causing brain circuitry dysfunctions in AD may take several years to develop …
A further update on the role of excitotoxicity in the pathogenesis of Parkinson's disease
Increased levels of extracellular glutamate and hyperactivation of glutamatergic receptors in
the basal ganglia trigger a critical cascade of events involving both intracellular pathways …
the basal ganglia trigger a critical cascade of events involving both intracellular pathways …
Neuroglial transmission
V Gundersen, J Storm-Mathisen… - Physiological …, 2015 - journals.physiology.org
Neuroglia, the “glue” that fills the space between neurons in the central nervous system,
takes active part in nerve cell signaling. Neuroglial cells, astroglia, oligodendroglia, and …
takes active part in nerve cell signaling. Neuroglial cells, astroglia, oligodendroglia, and …
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …