Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Immunogenetic and environmental factors in age-related macular disease

S Brodzka, J Baszyński, K Rektor… - International Journal of …, 2024 - mdpi.com
Age-related macular degeneration (AMD) is a chronic disease, which often develops in
older people, but this is not the rule. AMD pathogenesis changes include the anatomical and …

Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation

D Li, J Chang, Y Wang, X Du, J Xu, J Cui… - Acta Neuropathologica …, 2024 - Springer
Activated microglia play an important role in driving photoreceptor degeneration-associated
neuroinflammation in the retina. Controlling pro-inflammatory activation of microglia holds …

Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration

Y Jiang, X Fu, M Shao, W Chang, H Zhang, Z Liu - Biomaterials, 2024 - Elsevier
In clinics, therapeutic proteins are commonly used to treat retinal diseases through
intraocular injection, the treatment which suffers from rather low patient compliance. Topical …

Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation …

C Yang, L Ge, X Yu, P Lazarovici, W Zheng - Molecules, 2024 - mdpi.com
Increased oxidative stress is one of the critical pathologies inducing age-related macular
degeneration (AMD), characterized by retinal pigment epithelial (RPE) cell damage and …

Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

J Zhang, X Sheng, Q Ding, Y Wang… - Neural Regeneration …, 2025 - journals.lww.com
Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular
degeneration. It causes local damage to photoreceptors, retinal pigment epithelium, and …

P38 MAPK signaling in the retina: effects of aging and age-related macular degeneration

NA Muraleva, NG Kolosova - International Journal of Molecular Sciences, 2023 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of irreversible visual
impairment worldwide. Age is the greatest risk factor for AMD but the underlying mechanism …

[HTML][HTML] SuperDopa (SD), SuperDopa amide (SDA) and Thioredoxin-mimetic peptides protect ARPE-19 cells from photic-and non-photic stress

MM Olchawa, G Szewczyk, M Lachish, T Sarna… - … of Photochemistry and …, 2024 - Elsevier
Oxidative stress and inflammation in the retinal pigment epithelium (RPE) cells have been
identified as significant risk factors in the development and progression of retinal associated …

[HTML][HTML] A Vicious NGF-p75NTR Positive Feedback Loop Exacerbates the Toxic Effects of Oxidative Damage in the Human Retinal Epithelial Cell Line ARPE-19

G Tringali, M Pizzoferrato, L Lisi, S Marinelli… - International Journal of …, 2023 - mdpi.com
In spite of its variety of biological activities, the clinical exploitation of human NGF (hNGF) is
currently limited to ocular pathologies. It is therefore interesting to test the effects of hNGF in …

Impact of COVID-19 pandemic on ocular disease: KNHANES 2015–2021

HJ Kim, YK Ryu, YJ Shin - Scientific Reports, 2024 - nature.com
The aim of this study was to evaluate the impact of COVID-19 on ocular diseases and
changes in risk factors before and after the COVID-19 pandemic. This study was conducted …