Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …

How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …

Sex ratio shifts in response to temperature are common in fish and reptiles. However, the
mechanism linking temperature during early development and sex ratios has remained …

Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …

Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin
remodeling and have crucial roles in numerous biological processes, largely through their …

Since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3) for the
treatment of acute promyelocytic leukemia (APL), the overall survival rate has improved …

Many different molecular mechanisms have been associated with PML-RARα-dependent
transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARα …