CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

Sarcoidosis is a systemic granulomatous disease of unknown cause. Sarcoidosis involving
the heart, ie, cardiac sarcoidosis, affects the prognosis of patients significantly as it may lead …

Abstract IFN-γ-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells
stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells …

BACKGROUND Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of
immune checkpoint immunotherapy (ICI), one which precludes the continuation of ICI. Yet …

Sarcoidosis is characterized by extensive local inflammation (granuloma, cytokine secretion)
associated with anergy (poor response to antigens in vitro and in vivo). We postulated that …

Background and aims Sarcoidosis is characterised by a compartmentalisation of CD4+ T
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …

Cytokines may be crucially involved in the pathogenesis of inflammatory bowel diseases
(IBD), but it remains controversial whether interferon (IFN)-γ, a typical proinflammatory …

Activated T lymphocytes accumulate early in atheroma formation and persist at sites of
lesion growth and rupture, suggesting that they may play an important role in the …

In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3,
CCR4, and CCR8 and migrate to their ligands: eotaxin, monocyte-derived chemokine …