ContextComplications of atherosclerosis cause most morbidity and mortality in patients with
diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy …

The morbidity caused by diabetes has traditionally been classified into macro-and
microvascular complications. Although macrovascular complications have received greater …

Individuals exhibiting precursor symptoms of diabetes mellitus or reaching diagnostic
thresholds for diabetes are at increased risk of death due to cardiovascular disease (CVD) …

Oxidants and free radicals are deleterious in many ways, and organisms employ numerous
approaches to block their production or limit their damage. Hydrogen atoms adjacent to …

Endothelin is a potent vasoconstrictor peptide isolated from endothelial cells and it induces
smooth muscle cell proliferation. Endothelin-1 secretion is increased in atheroma and …

Preeclampsia is a complex multifactorial disease. Placental oxidative stress, a result of
deficient spiral artery remodeling, plays an important role in the pathophysiology of …

Increased placental release of soluble VEGF receptor-1 (sFlt-1) is believed to play an
important role in the pathogenesis of preeclampsia (PE). Although the reason for increased …

Objective Active acromegaly is associated with increased mortality from cardiovascular
causes. Several studies have shown increased atherogenic risk factors and biomarkers of …

Cardiovascular disease (CVD) is the leading cause of death in Type 1 Diabetes (T1D). The
molecular basis for atherosclerosis in T1D is heavily influenced by hyperglycaemia and its …

Key elements in the maintenance of tissue homeostasis, blood vessels serve as the conduits
of circulation, transporting nutrients and oxygen to organs and tissues, and removing …