Cancer driver mutations: predictions and reality
Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of
them drive cancer progression, termed driver mutations. Driver mutations may vary between …
them drive cancer progression, termed driver mutations. Driver mutations may vary between …
Extrachromosomal DNA amplifications in cancer
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …
has been observed in most cancer types and is associated with worse patient outcome. The …
Mechanisms of APOBEC3 mutagenesis in human cancer cells
The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing …
challenging clinical management. Through a large series of whole-genome sequencing …
Map** extrachromosomal DNA amplifications during cancer progression
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer
progression, we detected and classified focal amplifications in 8,060 newly diagnosed …
progression, we detected and classified focal amplifications in 8,060 newly diagnosed …
Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Abstract Analysis of mutational signatures can reveal underlying molecular mechanisms of
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
Blocking genomic instability prevents acquired resistance to MAPK inhibitor therapy in melanoma
Blocking cancer genomic instability may prevent tumor diversification and escape from
therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing …
therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing …
[HTML][HTML] The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution
Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic
heterogeneity. In this study, we investigated the evolution of genomic signatures caused by …
heterogeneity. In this study, we investigated the evolution of genomic signatures caused by …