Loss and gain of functions mutations in the X-linked MECP2 (methyl-CpG-binding protein 2)
gene are responsible for a set of generally severe neurological disorders that can affect both …

Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the
development and maintenance of neurons in the brain, and human neurodevelopmental as …

The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …

Human pluripotent stem cell (hPSC)-derived retinal organoids (ROs) can efficiently and
reproducibly generate retinal neurons that have potential for use in cell replacement …

Adult hippocampal neurogenesis is important for preserving learning and memory‐related
cognitive functions. Physical exercise, especially voluntary running, is one of the strongest …

Mutations in the activity-dependent transcription factor MEF2C have been associated with
several neuropsychiatric disorders. Among these, autism spectrum disorder (ASD)-related …

Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder that is primarily
caused by mutations in the methyl CpG binding protein 2 gene (MECP2). RTT is the second …

A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a
common neuropathological feature in many neurodevelopmental disorders. Rett syndrome …

Studies on MECP2 function and its implications in Rett Syndrome (RTT) have traditionally
centered on neurons. Here, using human embryonic stem cell (hESC) lines, we modeled …

Rett syndrome (RTT) and CDKL5 deficiency disorder (CDD) are two rare X-linked
developmental brain disorders with overlap** but distinct phenotypic features. This review …