Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
Mouse models of Alzheimer's disease
M Yokoyama, H Kobayashi, L Tatsumi… - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …
Targeting CDK1 in cancer: mechanisms and implications
Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …
promising candidate targets for cancer treatment. These proteins complexed with cyclins …
Lessons learned from past cyclin-dependent kinase drug discovery efforts
Z **e, S Hou, X Yang, Y Duan, J Han… - Journal of Medicinal …, 2022 - ACS Publications
Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy
for treating various diseases, especially cancer. Over almost three decades, although great …
for treating various diseases, especially cancer. Over almost three decades, although great …
Network toxicological and molecular docking to investigate the mechanisms of toxicity of agricultural chemical Thiabendazole
J He, X Zhu, K Xu, Y Li, J Zhou - Chemosphere, 2024 - Elsevier
Food safety is closely linked to human health. Thiabendazole is widely used as a fungicide
and deodorant on agricultural products like vegetables and fruits to prevent fungal infections …
and deodorant on agricultural products like vegetables and fruits to prevent fungal infections …
Small molecule '4ab'induced autophagy and endoplasmic reticulum stress-mediated death of aggressive cancer cells grown under adherent and floating conditions
Metastasis is the leading cause of death in cancer patients and a major challenging aspect
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …
From structure modification to drug launch: A systematic review of the ongoing development of cyclin-dependent kinase inhibitors for multiple cancer therapy
Z Shi, L Tian, T Qiang, J Li, Y **ng, X Ren… - Journal of medicinal …, 2022 - ACS Publications
Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been
approved or have undergone clinical trials and their therapeutic application in multiple …
approved or have undergone clinical trials and their therapeutic application in multiple …
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …
Huntington's disease, present challenges in healthcare because of their complicated …
Neuronal cell death mechanisms in Alzheimer's disease: An insight
Regulated cell death (RCD) is an ordered and tightly orchestrated set of changes/signaling
events in both gene expression and protein activity and is responsible for normal …
events in both gene expression and protein activity and is responsible for normal …
[HTML][HTML] Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling
Repurposing approved drugs is an emerging therapeutic development strategy for
Alzheimer's disease (AD). The CDK4/6 inhibitor abemaciclib mesylate is an FDA-approved …
Alzheimer's disease (AD). The CDK4/6 inhibitor abemaciclib mesylate is an FDA-approved …