Astrocytes as key regulators of brain energy metabolism: new therapeutic perspectives

E Beard, S Lengacher, S Dias, PJ Magistretti… - Frontiers in …, 2022 - frontiersin.org
Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

The neuroscience of drug reward and addiction

ND Volkow, M Michaelides, R Baler - Physiological reviews, 2019 - journals.physiology.org
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Brain metabolism in health, aging, and neurodegeneration

S Camandola, MP Mattson - The EMBO journal, 2017 - embopress.org
Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …

The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging

HA Deery, R Di Paolo, C Moran, GF Egan… - …, 2023 - Wiley Online Library
The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …

Physical exercise and cognitive performance in the elderly: current perspectives

NJ Kirk-Sanchez, EL McGough - Clinical interventions in aging, 2014 - Taylor & Francis
In an aging population with increasing incidence of dementia and cognitive impairment,
strategies are needed to slow age-related decline and reduce disease-related cognitive …

Impact of diet and exercise interventions on cognition and brain health in older adults: a narrative review

MN Key, AN Szabo-Reed - Nutrients, 2023 - mdpi.com
The ability to preserve cognitive function and protect brain structure from the effects of the
aging process and neurodegenerative disease is the goal of non-pharmacologic, lifestyle …

Brain metabolic alterations in Alzheimer's disease

CG Ardanaz, MJ Ramírez, M Solas - International journal of molecular …, 2022 - mdpi.com
The brain is one of the most energy-consuming organs in the body. Satisfying such energy
demand requires compartmentalized, cell-specific metabolic processes, known to be …

Effects of aging in multisensory integration: a systematic review

AL De Dieuleveult, PC Siemonsma… - Frontiers in aging …, 2017 - frontiersin.org
Multisensory integration (MSI) is the integration by the brain of environmental information
acquired through more than one sense. Accurate MSI has been shown to be a key …

Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse

MR Lowerison, NVC Sekaran, W Zhang, Z Dong… - Scientific reports, 2022 - nature.com
Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

The beneficial effects of different types of exercise interventions on motor and cognitive functions in older age: a systematic review

O Levin, Y Netz, G Ziv - European Review of Aging and Physical Activity, 2017 - Springer
The decline in cognitive and motor functions with age affects the performance of the aging
healthy population in many daily life activities. Physical activity appears to mitigate this …