Abstract The World Health Organization (WHO) classification of central nervous system
(CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular …

Codeletion of chromosomal arms 1p and 19q, in conjunction with a mutation in the isocitrate
dehydrogenase 1 or 2 gene, is the molecular diagnostic criterion for oligodendroglioma, IDH …

Cell cycle regulator genes are major target of mutation in many human malignancies
including glioblastomas (GBMs). CDKN2A is one such tumor suppressor gene which …

Rationale and Objectives The classification of patients based on pathology and molecular
features is important for improving WHO grade II glioma patient prognosis, especially for the …

Several morphology-and polymerase chain reaction (PCR)-based methods for chromosome
1p 19q deletion status assessment are available. Important prerequisites for all molecular …

Abstract Introduction The European Organisation for Research and Treatment of Cancer
(EORTC) 22033-26033 clinical trial (NCT00182819) investigated whether initial …

The 1p/19q codeletion is the result of a translocation between chromosome 1 (Chr1p) and
chromosome 19 (Chr19q) with the loss of derivative (1; 19)(p10; q10) chromosome. The …

Background Fluorescence in situ hybridization (FISH) is a standard method for 1p/19q
codeletion testing in diffuse gliomas but occasionally renders erroneous results. Purpose To …

Abstract 1p/19q codeletion is a favorable prognostic marker of oligodendrogliomas.
Although fluorescence in situ hybridization (FISH) and microsatellite-based polymerase …

Background Complete deletion of both the short arm of chromosome 1 (1p) and the long arm
of chromosome 19 (19q), known as 1p/19q codeletion, is a mutation that can occur in …