Diagnosis of transmissible spongiform encephalopathies in animals: a review
D Gavier-Widén, MJ Stack, T Baron… - Journal of …, 2005 - journals.sagepub.com
Transmissible spongiform encephalopathies (TSEs) in animals include, among others,
bovine spongiform encephalopathy (BSE), scrapie, chronic wasting disease, and atypical …
bovine spongiform encephalopathy (BSE), scrapie, chronic wasting disease, and atypical …
Prion strain diversity
JC Bartz - Cold Spring Harbor perspectives in …, 2016 - perspectivesinmedicine.cshlp.org
Prion diseases affect a wide range of mammal species and are caused by a misfolded self-
propagating isoform (PrPSc) of the normal prion protein (PrPC). Distinct strains of prions …
propagating isoform (PrPSc) of the normal prion protein (PrPC). Distinct strains of prions …
Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie
L Gonzalez, S Martin, I Begara-McGorum… - Journal of comparative …, 2002 - Elsevier
Different cellular and neuroanatomical types of disease-specific prion protein (PrPd)
accumulation in the brain were identified in sheep of different breeds and PrP genotypes …
accumulation in the brain were identified in sheep of different breeds and PrP genotypes …
Rapid prion neuroinvasion following tongue infection
Food-borne transmission of prions can lead to infection of the gastrointestinal tract and
neuroinvasion via the splanchnic and vagus nerves. Here we report that the transmission of …
neuroinvasion via the splanchnic and vagus nerves. Here we report that the transmission of …
Distinct profiles of PrPd immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing
L Gonzalez, S Martin, M Jeffrey - Journal of General …, 2003 - microbiologyresearch.org
Previous studies have shown that the patterns of disease-specific prion protein (PrPd)
accumulation in the brain (the 'PrPd profile') of scrapie-affected sheep are mainly influenced …
accumulation in the brain (the 'PrPd profile') of scrapie-affected sheep are mainly influenced …
BSE in sheep bred for resistance to infection
F Houston, W Goldmann, A Chong, M Jeffrey… - Nature, 2003 - nature.com
Selective breeding for disease-resistant genotypes is being pursued as a means of
eradicating scrapie (and bovine spongiform encephalopathy (BSE), if it is present) from …
eradicating scrapie (and bovine spongiform encephalopathy (BSE), if it is present) from …
Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep
JPM Langeveld, JG Jacobs, JHF Erkens… - BMC veterinary …, 2006 - Springer
Background Diagnosis based on prion detection in lymph nodes of sheep and goats can
improve active surveillance for scrapie and, if it were circulating, for bovine spongiform …
improve active surveillance for scrapie and, if it were circulating, for bovine spongiform …
Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein
CMA Thuring, JHF Erkens, JG Jacobs… - Journal of clinical …, 2004 - Am Soc Microbiol
ABSTRACT A procedure for discrimination between scrapie and bovine spongiform
encephalopathy (BSE) in sheep is of importance for establishing whether BSE has entered …
encephalopathy (BSE) in sheep is of importance for establishing whether BSE has entered …
Immunohistochemical features of PrPd accumulation in natural and experimental goat transmissible spongiform encephalopathies
M Jeffrey, S Martin, L Gonzalez, J Foster… - Journal of comparative …, 2006 - Elsevier
Scrapie is a transmissible spongiform encephalopathy (TSE) or prion disease, which
naturally affects sheep and goats. Immunohistochemical epitope map** of abnormal PrP …
naturally affects sheep and goats. Immunohistochemical epitope map** of abnormal PrP …
Experimental transmission of atypical scrapie to sheep
MM Simmons, T Konold, HA Simmons… - BMC veterinary …, 2007 - Springer
Background Active surveillance for transmissible spongiform encephalopathies in small
ruminants has been an EU regulatory requirement since 2002. A number of European …
ruminants has been an EU regulatory requirement since 2002. A number of European …