The previous edition of the consensus guidelines of the International Workshop on Chronic
Lymphocytic Leukemia (iwCLL), published in 2008, has found broad acceptance by …

Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the
B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and …

Tumor immunotherapy with T lymphocytes, which can recognize and destroy malignant
cells, has been limited by the ability to isolate and expand T cells restricted to tumor …

Abstract Mutations in TP53, NOTCH1, and SF3B1 were analyzed in the CLL8 study
evaluating first-line therapy with fludarabine and cyclophosphamide (FC) or FC with …

Background On the basis of promising results that were reported in several phase 2 trials,
we investigated whether the addition of the monoclonal antibody rituximab to first-line …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Background Fluorescence in situ hybridization has improved the detection of genomic
aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal …

Standardized criteria for diagnosis and response assessment are needed to interpret and
compare clinical trials and for approval of new therapeutic agents by regulatory agencies …

Chemotherapy, one of the principal approaches for cancer patients, plays a crucial role in
controlling tumor progression. Clinically, tumors reveal a satisfactory response following the …