Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies
MA McArdle, OM Finucane, RM Connaughton… - Frontiers in …, 2013 - frontiersin.org
Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …
[HTML][HTML] The interplay between obesity and inflammation
I Savulescu-Fiedler, R Mihalcea, S Dragosloveanu… - Life, 2024 - mdpi.com
Obesity is an important condition affecting the quality of life of numerous patients and
increasing their associated risk for multiple diseases, including tumors and immune …
increasing their associated risk for multiple diseases, including tumors and immune …
Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
W Liang, AL Menke, A Driessen, GH Koek… - PloS one, 2014 - journals.plos.org
Background and aims The recently developed histological scoring system for non-alcoholic
fatty liver disease (NAFLD) by the NASH Clinical Research Network (NASH-CRN) has been …
fatty liver disease (NAFLD) by the NASH Clinical Research Network (NASH-CRN) has been …
The role of tissue macrophage‐mediated inflammation on NAFLD pathogenesis and its clinical implications
The obese phenotype is characterized by a state of chronic low‐grade systemic
inflammation that contributes to the development of comorbidities, including nonalcoholic …
inflammation that contributes to the development of comorbidities, including nonalcoholic …
High-throughput proteomics uncovers exercise training and type 2 diabetes–induced changes in human white adipose tissue
JK Larsen, R Kruse, N Sahebekhtiari… - Science …, 2023 - science.org
White adipose tissue (WAT) is important for metabolic homeostasis. We established the
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …
Role of macrophage migration inhibitory factor in obesity, insulin resistance, type 2 diabetes, and associated hepatic co-morbidities: a comprehensive review of …
MC Morrison, R Kleemann - Frontiers in immunology, 2015 - frontiersin.org
Obesity is associated with a chronic low-grade inflammatory state that drives the
development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes …
development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes …
Innate immunity and adipose tissue biology
A Schäffler, J Schölmerich - Trends in immunology, 2010 - cell.com
The understanding of the role of adipose tissue has changed from a lipid storage organ to
an endocrine and immunologically active organ. Here, we summarize the evidence for an …
an endocrine and immunologically active organ. Here, we summarize the evidence for an …
Macrophage migration inhibitory factor (MIF): a promising biomarker
G Grieb, M Merk, J Bernhagen… - Drug news & …, 2010 - pmc.ncbi.nlm.nih.gov
Macrophage migration inhibitory (MIF) factor is an immunoregulatory cytokine whose effect
on arresting random immune cell movement was recognized several decades ago. Despite …
on arresting random immune cell movement was recognized several decades ago. Despite …
High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice
M Gao, Y Ma, D Liu - PloS one, 2015 - journals.plos.org
High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity
and obesity related metabolic complications. In this study, we determined HFD induced …
and obesity related metabolic complications. In this study, we determined HFD induced …
The role of fat and inflammation in the pathogenesis and management of osteoarthritis
H Urban, CB Little - Rheumatology, 2018 - academic.oup.com
OA is a complex disease involving mechanical, metabolic and inflammatory contributions to
its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its …
its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its …