Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

[HTML][HTML] Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases

Z Jiang, X Yin, M Wang, T Chen, Y Wang, Z Gao… - Aging and …, 2022 - ncbi.nlm.nih.gov
The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …

Neuroprotection by the ketogenic diet: evidence and controversies

SM Gough, A Casella, KJ Ortega, AS Hackam - Frontiers in Nutrition, 2021 - frontiersin.org
The ketogenic diet (KD) is a high-fat low-carbohydrate diet that has been used for decades
as a non-pharmacologic approach to treat metabolic disorders and refractory pediatric …

Metabolic Messengers: ketone bodies

AB Nelson, ED Queathem, P Puchalska… - Nature …, 2023 - nature.com
Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Mitochondrial sirtuins in Parkinson's disease

L He, J Wang, Y Yang, J Li, H Tu - Neurochemical Research, 2022 - Springer
Abstract Parkinson's disease (PD), the main risk factor for which is age, is one of the most
common neurodegenerative diseases and imposes a substantial burden on affected …

β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson's disease models via inhibiting STAT3/NLRP3/GSDMD pathway

Z Jiang, X Yin, M Wang, Y Wang, F Li, Y Gao… - International …, 2022 - Elsevier
Background Parkinson's disease (PD) is a common neurodegenerative disease
characterized by motor symptoms and non-motor symptoms, and affects millions of people …

Vancomycin pretreatment on MPTP-induced Parkinson's disease mice exerts neuroprotection by suppressing inflammation both in brain and gut

C Cui, H Hong, Y Shi, Y Zhou, CM Qiao… - Journal of Neuroimmune …, 2023 - Springer
A growing body of evidence implies that gut microbiota was involved in pathogenesis of
Parkinson's disease (PD), but the mechanism is still unclear. The aim of this study is to …

Ketone body β-hydroxybutyric acid ameliorates dopaminergic neuron injury through modulating zinc finger protein 36/Acyl-CoA synthetase long-chain family member …

X Yu, Y Yang, B Zhang, G Han, J Yu, Q Yu, L Zhang - Neuroscience, 2023 - Elsevier
Abstract β-hydroxybutyrate (BHB) is one of main component of ketone body, which plays an
important protective role in various tissues and organs. Whereas, its exact regulatory roles …

Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle

HM Al-Kuraishy, MS Jabir, AK Albuhadily… - Ageing Research …, 2024 - Elsevier
The ketogenic diet (KD) is a low-carbohydrate, adequate protein and high-fat diet. KD is
primarily used to treat refractory epilepsy. KD was shown to be effective in treating different …

Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials

MG Grammatikopoulou, G Tousinas, C Balodimou… - Maturitas, 2022 - Elsevier
Objective The aim of the present systematic review was to assess the efficacy of ketogenic
therapy in Parkinson's disease (PD), using all available data from randomized controlled …