The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Introduction During the last decades, the ever-increasing proportion of patients with cancer
has been led to serious concerns worldwide. Therefore, the development and use of novel …

It is well known that neurodegenerative diseases' development and progression are
accelerated due to oxidative stress and inflammation, which result in impairment of …

Infectious disease is one of the top 10 causes of death worldwide, especially in low-income
countries. The extensive use of antibiotics has led to an increase in antibiotic resistance …

Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein
and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to …

The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …

Abstract Background Coronaviruses such as Severe Acute Respiratory Syndrome
coronavirus (SARS), Middle Eastern Respiratory Syndrome (MERS) and Severe Acute …

Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the
loss of dopaminergic neurons within the substantia nigra. The specific molecular …

Gallic acid (GA), a dietary phenolic acid with potent antioxidant activity, is widely distributed
in edible plants. GA has been applied in the food industry as an antimicrobial agent, food …

The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …