Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Aerobic organisms possess numerous antioxidant enzymatic families, including catalases,
superoxide dismutases (SODs), peroxiredoxins (PRDXs), and glutathione peroxidases …

Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety
of tumor types, such as breast cancer. Despite the long history of DOX, the mechanistic …

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Mutations in the tumor suppressor TP53 cause cancer and impart poor chemotherapeutic
responses, reportedly through loss-of-function, dominant-negative effects and gain-of …

According to numerous animal studies, adverse environmental stimuli, including physical,
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …

Lung cancer is a main cause of death all over the world with a high incidence rate.
Metastasis into neighboring and distant tissues as well as resistance of cancer cells to …

Oxidative stress is a state of excess of prooxidative species relative to the antioxidant
defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this …