Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins
undergo constant endo/exocytic shuttling to facilitate the dynamic regulation of cell …

During viral infection the first challenge that viruses have to overcome is gaining access to
the intracellular compartment. The infection process starts when the virus contacts the …

All multicellular animals express receptors for growth factors (GFs) and extracellular matrix
(ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and …

Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and
cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules …

Viruses successfully infect host cells by initially binding to the surfaces of the cells, followed
by an intricate entry process. As multifunctional heterodimeric cell-surface receptor …

In the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome, open
reading frames (ORFs) encode for viral accessory proteins. Among these, Orf7a structurally …

Reovirus infection requires the concerted action of viral and host factors to promote cell
entry. After interaction of reovirus attachment protein σ1 with cell-surface carbohydrates and …

The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an
extracellular matrix receptor for collagens and/or laminins [55, 56]. It is now recognized that …