Pyruvate kinase M2 and cancer: the role of PKM2 in promoting tumorigenesis
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …
Flavonoids targeting HIF-1: Implications on cancer metabolism
Simple Summary This comprehensive review discusses the anticancer effects of plant
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …
Emerging role of exosomes in liquid biopsy for monitoring prostate cancer invasion and metastasis
Prostate cancer (PCa) is the most common solid tumor in men. While patients with local PCa
have better prognostic survival, patients with metastatic PCa have relatively high mortality …
have better prognostic survival, patients with metastatic PCa have relatively high mortality …
Hypoxia‐inducible factor‐1: A potential target to treat acute lung injury
Y Liu, D **ang, H Zhang, H Yao… - Oxidative medicine and …, 2020 - Wiley Online Library
Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra‐
and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the …
and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the …
Role of PKM2-mediated immunometabolic reprogramming on development of cytokine storm
Z Liu, Y Le, H Chen, J Zhu, D Lu - Frontiers in immunology, 2021 - frontiersin.org
The cytokine storm is a marker of severity of various diseases and increased mortality. The
altered metabolic profile and energy generation of immune cells affects their activation …
altered metabolic profile and energy generation of immune cells affects their activation …
[HTML][HTML] Dietary approaches for exploiting metabolic vulnerabilities in cancer
Renewed interest in tumor metabolism sparked an enthusiasm for dietary interventions to
prevent and treat cancer. Changes in diet impact circulating nutrient levels in the plasma …
prevent and treat cancer. Changes in diet impact circulating nutrient levels in the plasma …
Placental proteome in late-onset of fetal growth restriction
T Gęca, A Stupak, R Nawrot… - Molecular …, 2022 - spandidos-publications.com
Fetal growth restriction (FGR) occurs when the fetus does not reach its genetically
programmed intrauterine potential for growth and affects~ 5–10% of pregnancies. This …
programmed intrauterine potential for growth and affects~ 5–10% of pregnancies. This …
Metformin inhibits epithelial‑mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF‑1α/PKM2/STAT3 pathway
W Yin, Y Liu, X Liu, X Ma, B Sun… - Oncology …, 2021 - spandidos-publications.com
Epithelial‑mesenchymal transition (EMT) serves an important role in the formation and
development of various types of cancer, including oral squamous cell carcinoma (OSCC) …
development of various types of cancer, including oral squamous cell carcinoma (OSCC) …
[HTML][HTML] Emerging roles of exosome-derived biomarkers in cancer theranostics: messages from novel protein targets
J Cheng, X Wang, X Yuan, G Liu… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Effective biomarkers that guide therapeutics with limited adverse effects, have emerged as
attractive research topics in cancer diagnosis and treatment. Cancer-derived exosomes, a …
attractive research topics in cancer diagnosis and treatment. Cancer-derived exosomes, a …
Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential …
Prostate cancer (CaP) is the most diagnosed cancer in males and the second leading cause
of cancer deaths. Patients with localized tumors are generally curable. However, no curative …
of cancer deaths. Patients with localized tumors are generally curable. However, no curative …