Model systems and organisms for addressing inter-and intra-species variability in risk assessment
Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …
remains a long-standing challenge in human health risk assessment that is typically …
[HTML][HTML] Chemical safety and the exposome
Air pollution and rapid chemical intensification are major threats to the environment and
human health. Today, we have produced over 350,000 chemicals, and current testing …
human health. Today, we have produced over 350,000 chemicals, and current testing …
[HTML][HTML] Altered gut microbiota community structure and correlated immune system changes in dibutyl phthalate exposed mice
Di-n-butyl phthalate (DBP) is a ubiquitous environmental contaminant linked with various
adverse health effects, including immune system dysfunction. Gut microbial dysbiosis can …
adverse health effects, including immune system dysfunction. Gut microbial dysbiosis can …
[HTML][HTML] Personalized mixture toxicity testing: A proof-of-principle in vitro study evaluating the steroidogenic effects of reconstructed contaminant mixtures measured in …
Chemical risk assessments typically focus on single substances, often overlooking real-
world co-exposures to chemical mixtures. Mixture toxicology studies using representative …
world co-exposures to chemical mixtures. Mixture toxicology studies using representative …
Perfluorooctanesulfonic acid (PFOS) induced cancer related DNA methylation alterations in human breast cells: A whole genome methylome study
DNA methylation plays a pivotal role in cancer. The ubiquitous contaminant
perfluorooctanesulfonic acid (PFOS) has been epidemiologically associated with breast …
perfluorooctanesulfonic acid (PFOS) has been epidemiologically associated with breast …
Data-Driven Characterization of Genetic Variability in Disease Pathways and Pesticide-Induced Nervous System Disease in the United States Population
Background: Genetic susceptibility to chemicals is incompletely characterized. However,
nervous system disease development following pesticide exposure can vary in a population …
nervous system disease development following pesticide exposure can vary in a population …
[HTML][HTML] Heavy metals are liver fibrosis risk factors in people without traditional liver disease etiologies
Liver fibrosis is an important predictor of mortality. Liver disease case definitions changed in
2023. These definitions include an easily over-looked group with no traditional etiology …
2023. These definitions include an easily over-looked group with no traditional etiology …
New approach methodologies to address population variability and susceptibility
Human health risk assessment aims to characterize the potential harmful effects of chemical
exposures to ensure the safety of broad populations. Among these broad populations are …
exposures to ensure the safety of broad populations. Among these broad populations are …
Genetic variability in pathways associates with pesticide-induced nervous system disease in the United States
Nervous system disease development following pesticide exposure can vary in a
population, but genetic susceptibility to chemicals is poorly characterized. We developed a …
population, but genetic susceptibility to chemicals is poorly characterized. We developed a …
Change-plane analysis for subgroup detection with a continuous treatment
Detecting and characterizing subgroups with differential effects of a binary treatment has
been widely studied and led to improvements in patient outcomes and population risk …
been widely studied and led to improvements in patient outcomes and population risk …