Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

The dearth of new medicines effective against antibiotic-resistant bacteria presents a
growing global public health concern. For more than five decades, the search for new …

Efficiency of protein synthesis on the ribosome is strongly affected by the amino acid
composition of the assembled amino acid chain. Challenging sequences include proline …

The prokaryotic translation elongation factor P (EF-P) and the eukaryotic/archaeal
counterparts eIF5A/aIF5A are proteins that serve a crucial role in mitigating ribosomal …

Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …

Having multiple rounds of translation of the same mRNA creates dynamic complexities
along with opportunities for regulation related to ribosome pausing and stalling at specific …

Streptococcal infections are usually treated with beta-lactam antibiotics, but, in case of
allergic patients or reduced antibiotic susceptibility, macrolides and fluoroquinolones are the …

HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition
to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr …

In the 20th century, the discovery of antibiotics played an essential role in the fight against
infectious diseases, including meningitis, typhoid fever, pneumonia and Mycobacterium …