Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its
association with an aggressive tumour phenotype and therapeutic resistance. Given its …

Purpose: Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who
might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our …

Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …

Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …

Hypoxia is a hallmark of the tumor microenvironment and contributes to tumor malignant
phenotypes. Hypoxia-inducible factor (HIF) is a master regulator of intratumoral hypoxia and …

The future of medicine lies in early diagnosis and individually tailored treatments, a concept
that has been designated 'personalised medicine'(PM), which aims to deliver the right …