The mammalian embryo cannot develop without the placenta. Its specialized cells
(trophoblast, endoderm, and extraembryonic mesoderm) form early in development. They …

The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The
primary function of gastrulation is the correct placement of precursor tissues for subsequent …

We have found that the mammalian Ran GTPase–activating protein RanGAP1 is highly
concentrated at the cytoplasmic periphery of the nuclear pore complex (NPC), where it …

Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins
and ribnucleoproteins across the nuclear pore complex (NPC). A key regulator of the Ran …

Expression of HNF-4, a transcription factor in the steroid hormone receptor superfamily, is
detected only in the visceral endoderm of mouse embryos during gastrulation and is …

Increasing attention has focused on the significance of RNA in sperm, in light of its
contribution to the birth and long-term health of a child, role in sperm function and diagnostic …

Protein arginine N-methyltransferases have been implicated in a variety of processes,
including cell proliferation, signal transduction, and protein trafficking. In this study, we have …

Yin Yang 1 (YY1) is a zinc finger-containing transcription factor and a target of viral
oncoproteins. To determine the biological role of YY1 in mammalian development, we …

A mouse mutation, termed jumonji (jmj), was generated by a gene trap strategy. Expression
of the trapped gene (jmj gene), as monitored by X-gal staining, was detected predominantly …

Luecine-rich repeats are short sequence motifs present in over sixty proteins, all of which
appear to be involved in protein—protein interactions. The crystal structure of ribonuclease …