The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs
ST Diepstraten, MA Anderson, PE Czabotar… - Nature Reviews …, 2022 - nature.com
Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …
The role of non-coding RNAs in oncology
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
Healthy effects of plant polyphenols: molecular mechanisms
The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …
accompanied by a progressively greater rate of degenerative diseases associated with …
[HTML][HTML] MicroRNA: A signature for cancer progression
MicroRNAs (miRNAs) are a group of small non-coding RNAs that post-transcriptionally
control expression of genes by targeting mRNAs. miRNA alterations partake in the …
control expression of genes by targeting mRNAs. miRNA alterations partake in the …
Classical and noncanonical functions of miRNAs in cancers
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …
progression of human cancers. The molecular events responsible for the widespread …
MicroRNAs and complex diseases: from experimental results to computational models
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …
viruses and animals. As one of the most important components in the cell, miRNAs play a …
miRNAs driving diagnosis, progression, and drug resistance in multiple myeloma
Multiple myeloma (MM) is a tumor of transformed plasma cells. It's the second most common
hematologic cancer after non-Hodgkin lymphoma. MM is a complex disease with many …
hematologic cancer after non-Hodgkin lymphoma. MM is a complex disease with many …
Regulation of microRNA biogenesis
M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
CL Au Yeung, NN Co, T Tsuruga, TL Yeung… - Nature …, 2016 - nature.com
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum.
However, the omental stromal cell-derived molecular determinants that modulate ovarian …
However, the omental stromal cell-derived molecular determinants that modulate ovarian …
The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics
D Bautista-Sánchez, C Arriaga-Canon… - … Therapy-Nucleic Acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …
expression via base-pairing complementarity. Their role in cancer can be related to tumor …