The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs

ST Diepstraten, MA Anderson, PE Czabotar… - Nature Reviews …, 2022 - nature.com
Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Healthy effects of plant polyphenols: molecular mechanisms

M Leri, M Scuto, ML Ontario, V Calabrese… - International journal of …, 2020 - mdpi.com
The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

[HTML][HTML] MicroRNA: A signature for cancer progression

BM Hussen, HJ Hidayat, A Salihi, DK Sabir… - Biomedicine & …, 2021 - Elsevier
MicroRNAs (miRNAs) are a group of small non-coding RNAs that post-transcriptionally
control expression of genes by targeting mRNAs. miRNA alterations partake in the …

Classical and noncanonical functions of miRNAs in cancers

MP Dragomir, E Knutsen, GA Calin - Trends in Genetics, 2022 - cell.com
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …

MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D **e, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

miRNAs driving diagnosis, progression, and drug resistance in multiple myeloma

MA Elkady, AM Yehia, EGE Elsakka… - … -Research and Practice, 2023 - Elsevier
Multiple myeloma (MM) is a tumor of transformed plasma cells. It's the second most common
hematologic cancer after non-Hodgkin lymphoma. MM is a complex disease with many …

Regulation of microRNA biogenesis

M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

CL Au Yeung, NN Co, T Tsuruga, TL Yeung… - Nature …, 2016 - nature.com
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum.
However, the omental stromal cell-derived molecular determinants that modulate ovarian …

The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics

D Bautista-Sánchez, C Arriaga-Canon… - … Therapy-Nucleic Acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …