The S100B protein: A multifaceted pathogenic factor more than a biomarker

F Michetti, ME Clementi, R Di Liddo, F Valeriani… - International Journal of …, 2023 - mdpi.com
S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

Blood biomarkers in epilepsy

RK Banote, S Akel, J Zelano - Acta Neurologica Scandinavica, 2022 - Wiley Online Library
Robust and accessible biomarkers are greatly needed in epilepsy. Diagnostic and
prognostic precision in the clinic needs to improve, and there is a need for objective …

Fluid biomarkers of neuro-glial injury in human status epilepticus: a systematic review

G Giovannini, S Meletti - International Journal of Molecular Sciences, 2023 - mdpi.com
As per the latest ILAE definition, status epilepticus (SE) may lead to long-term irreversible
consequences, such as neuronal death, neuronal injury, and alterations in neuronal …

Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis

S Vishwakarma, S Singh, TG Singh - Molecular Biology Reports, 2022 - Springer
Epileptic seizure-induced brain injuries include activation of neuroimmune response with
activation of microglia, astrocytes cells releasing neurotoxic inflammatory mediators …

Growing role of S100B protein as a putative therapeutic target for neurological-and nonneurological-disorders

F Michetti, G Di Sante, ME Clementi… - Neuroscience & …, 2021 - Elsevier
S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

Cerebral biomarkers and blood-brain barrier integrity in preeclampsia

T Friis, AK Wikström, J Acurio, J León, H Zetterberg… - Cells, 2022 - mdpi.com
Cerebral complications in preeclampsia contribute substantially to maternal mortality and
morbidity. There is a lack of reliable and accessible predictors for preeclampsia-related …

Mini review: Current status and perspective of S100B protein as a biomarker in daily clinical practice for diagnosis and prognosticating of clinical outcome in patients …

T Abboud, V Rohde, D Mielke - BMC neuroscience, 2023 - Springer
Prognosticating the clinical outcome of neurological diseases is essential to guide treatment
and facilitate decision-making. It usually depends on clinical and radiological findings …

Assessment of prognostic biomarkers in sudden sensorineural hearing loss: a systematic review and meta-analysis

S Niknazar, N Bazgir, V Shafaei, HA Abbaszadeh… - Clinical …, 2023 - Elsevier
Sudden sensorineural hearing loss (SSNHL) is defined as hearing loss of more than 30 dB
in less than 72 h. SSNHL is a frequent complaint and an emergency in otolaryngology …

[HTML][HTML] Neuro-glial degeneration in Status Epilepticus: Exploring the role of serum levels of Neurofilament light chains and S100B as prognostic biomarkers for short …

G Giovannini, R Bedin, N Orlandi, G Turchi… - Epilepsy & Behavior, 2023 - Elsevier
Background The last ILAE definition of Status Epilepticus (SE) highlights that the persistence
of the epileptic activity per se could determine irreversible brain damages that could be …

Combined transcriptomics and proteomics forecast analysis for potential biomarker in the acute phase of temporal lobe epilepsy

C Huang, Z You, Y He, J Li, Y Liu, C Peng… - Frontiers in …, 2023 - frontiersin.org
Background Temporal lobe epilepsy (TLE) is a common chronic episodic illness of the
nervous system. However, the precise mechanisms of dysfunction and diagnostic …