HLA-G: an immune checkpoint molecule
ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …
HLA‐G as a tolerogenic molecule in transplantation and pregnancy
HLA‐G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or
allograft transplantation, the expression of HLA‐G has been related to a better acceptance of …
allograft transplantation, the expression of HLA‐G has been related to a better acceptance of …
Trained memory of human uterine NK cells enhances their function in subsequent pregnancies
M Gamliel, D Goldman-Wohl, B Isaacson, C Gur… - Immunity, 2018 - cell.com
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast
invasion and angiogenesis. Several diseases of poor placental development are associated …
invasion and angiogenesis. Several diseases of poor placental development are associated …
KIR2DL4 (CD158d): an activation receptor for HLA-G
KIR2DL4 is an unusual killer cell immunoglobulin-like receptor (KIR) family member in terms
of its structure, expression, cellular localization, and signaling properties. The most …
of its structure, expression, cellular localization, and signaling properties. The most …
Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
Natural killer (NK) cells, which have an essential role in immune defense, also contribute to
reproductive success. NK cells are abundant at the maternal–fetal interface, where soluble …
reproductive success. NK cells are abundant at the maternal–fetal interface, where soluble …
MiRNA-mediated control of HLA-G expression and function
I Manaster, D Goldman-Wohl, C Greenfield… - PloS one, 2012 - journals.plos.org
HLA-G is a non-classical HLA class-Ib molecule expressed mainly by the extravillous
cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects …
cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects …
Generation of hypoimmunogenic human pluripotent stem cells via expression of membrane-bound and secreted β2m-HLA-G fusion proteins
Allogeneic immune rejection is a major barrier for the application of human pluripotent stem
cells (hPSCs) in regenerative medicine. A broad spectrum of immune cells, including T cells …
cells (hPSCs) in regenerative medicine. A broad spectrum of immune cells, including T cells …
The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients
L König, S Kasimir-Bauer, O Hoffmann, AK Bittner… - Human immunology, 2016 - Elsevier
The non-classical human leukocyte antigen G (HLA-G) molecule and its soluble forms exert
multiple immune suppressive regulatory functions in malignancy and in stem cells …
multiple immune suppressive regulatory functions in malignancy and in stem cells …
HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction
The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK)
cells. Studies to address the role of these abundant human NK cells at the maternal/fetal …
cells. Studies to address the role of these abundant human NK cells at the maternal/fetal …
Activating killer cell Ig-like receptors in health and disease
Expression of non-rearranged HLA class I-binding receptors characterizes human and
mouse NK cells. The postulation of the missing-self hypothesis some 30 years ago triggered …
mouse NK cells. The postulation of the missing-self hypothesis some 30 years ago triggered …