Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …

Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still develo** based on the …

Excitatory activity in the CNS is predominately mediated by l-glutamate through several
families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate …

Subunit-selective inhibition of N-methyl-d-aspartate receptors (NMDARs) is a promising
therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer's and …

N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have
been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting …

Background/Objectives: Leishmaniasis is one of the 20 Neglected Tropical Diseases
according to the WHO, affecting approximately 12 million people in four continents …

The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by L-
glutamate and glycine, plays a major role in the synaptic plasticity underlying learning and …

Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and
excitatory signaling in the brain. Introduction: In this disease, the targets are active in …

Background: NMDA (N-methyl-D-aspartate) receptor is one of the ionotropic receptor
subtypes of glutamate, the most abundant excitatory neurotransmitter in the human brain …