Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - ahajournals.org
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - ahajournals.org
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

AP Patel, M Wang, Y Ruan, S Koyama, SL Clarke… - Nature Medicine, 2023 - nature.com
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …

Large-scale integration of the plasma proteome with genetics and disease

E Ferkingstad, P Sulem, BA Atlason… - Nature …, 2021 - nature.com
The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …

Multi-ancestry polygenic mechanisms of type 2 diabetes

K Smith, AJ Deutsch, C McGrail, H Kim, S Hsu… - Nature medicine, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for
which the underlying biological mechanisms are not fully understood. In this study, we …

Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations

C Ke, KMV Narayan, JCN Chan, P Jha… - Nature Reviews …, 2022 - nature.com
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …

Genetics of diabetes mellitus and diabetes complications

JB Cole, JC Florez - Nature reviews nephrology, 2020 - nature.com
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind …

T Kadowaki, J Isendahl, U Khalid, SY Lee… - The lancet Diabetes & …, 2022 - thelancet.com
Background Semaglutide 2· 4 mg once weekly has been investigated for weight
management in global populations. Differences exist between Asian and non-Asian …